Glycomine is driven to develop therapies that provide significant improvements to the quality of life for patients and families with serious rare diseases. Our team has a diverse background of drug development experience, scientific and medical expertise, and a spirit of collaboration and teamwork. We are always looking for passionate and talented individuals who share our mission.
Glycomine is an equal opportunity employer, and we are dedicated to creating an inclusive environment for all employees. We respect the diversity of our workforce and applicants and encourage the expression of different cultures, backgrounds, and viewpoints.
We are located in major life science industry hubs in San Francisco, Boston, and Research Triangle Park where our team can access resources and come together. We also support remote and at-home work.
San Carlos, California
Glycomine is driven to develop therapies that provide significant improvements to the quality of life for patients and families with serious rare diseases. Our team has a diverse background of drug development experience, scientific and medical expertise, and a spirit of collaboration and teamwork. This is an exciting period of growth for the company, and we are seeking passionate and talented individuals who share our mission.
Addressing unmet medical needs of patients suffering from rare genetic diseases provides tremendous drive and meaning to what we do at Glycomine. We seek a talented and successful individual that deeply desires to participate in the process to discover and develop medicines that change a patient’s life forever. The successful candidate will play an important role in the advancement of the current clinical program (GLM101) as well as pipeline projects.
In this leadership role, you will lead and direct all in vitro biochemical and cellular pharmacology activities to support Glycomine’s lead clinical program as well as follow-on pipeline projects. You will be charged with expanding, mentoring, and developing a strong and talented in vitro pharmacology team of Scientists and Research Associates to support you in your goals. This role will bring key scientific knowledge, expertise, and leadership to the company. Reporting to the CSO, and as a key member of the Research Leadership Team, you will play a key role in identifying lead pipeline opportunities and establishing a scientific approach to vet and advance key programs to proof of concept and then to Development Candidate stage and beyond.
REPORTS TO: Chief Scientific Officer
- Build and lead a strong in vitro pharmacology team.
- Develop, optimize, and execute medium to high-throughput, robust, scientifically sound, and physiologically relevant in vitro biochemical and cell-based assays to support the lead program and follow on pipeline projects.
- Generate actionable data to advance programs from hit to lead and to support candidate drug nomination.
- Drive towards success with a result-driven attitude.
- Act as a hands-on leader to run laboratory operations in our San Carlos, California site.
- Identify and manage collaborations with CROs and external key opinion leaders.
- Partner with the CSO and other key company leaders to drive compelling additional therapeutic indication(s) for our platform.
- Generate key POC in vitro pharmacology data for high priority projects.
- Develop compelling data sets to support business development activities aimed at broadening the pipeline and expanding the utility of the platform and publishing in peer-reviewed journals.
- PhD with 10+ years of experience in drug discovery and research activities.
- Demonstrated ability of team building and leadership in a fast-paced environment, with proven record of achievement and success.
- Breadth of industry experience with multiple therapeutic areas, with a focus on rare genetic diseases.
- Strong expertise and demonstrated success in developing and implementing various biochemical and cellular pharmacology assays to support lead discovery and optimization.
- Demonstrated success running outsourced assays and managing FTEs at multiple CROs in parallel.
- Expert level knowledge of physiologically relevant primary in vitro cell models of disease with demonstrated success using such models to characterize complex disease pathways and to contribute to lead discovery and optimization.
- Top tier scientific thinking and drug discovery experience as demonstrated through contributions to pipeline advancement, publications and patents.
- Track record of leading research efforts from target validation through development candidate nomination.
- Good knowledge of lipid nanoparticle (LNP) development and optimization is strongly recommended.
- Familiarity with glycosylation pathways and their associated diseases is a plus.
- Experience working across disciplines and successfully partnering with leaders of various functional areas such as Chemistry, DMPK, In vivo Pharmacology, Preclinical and Clinical.
- Results driven, innovative, and passionate about science.
- Adheres to the “Attitude, Motivation and Commitment” success framework.
- Highly analytical, nimble, agile, resourceful, and strong problem solver.
- Strong collaboration skills for enabling high individual and high team performance.
- Strong ability to interface well at leadership team.
- Comfortable making informed judgment calls with imperfect or incomplete information.
- Ready to play a key role in creating a thoughtful, respectful, continuous learning, action-oriented, product-focused, patient-minded and value seeking culture.
- Excellent communicator with effective written, oral and data presentation skills.
Glycomine is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(K), FSA, and much more.
To apply, please submit a cover letter and your resume to careers@glycomine.com or click the submit button below to send an email.
San Carlos, California
Glycomine is driven to develop therapies that provide significant improvements to the quality of life for patients and families with serious rare diseases. Our team has a diverse background of drug development experience, scientific and medical expertise, and a spirit of collaboration and teamwork. This is an exciting period of growth for the company, and we are seeking passionate and talented individuals who share our mission.
Reporting to the Head-Translational Sciences, the successful candidate will play an important role in the advancement of new therapeutic indications as well as supporting current pipeline programs. In this role, you will lead and direct efforts to support Glycomine’s pipeline project expansion by developing and implementing novel biochemical and cell-based assays as well as contributing to translatable pharmacodynamic biomarker discovery. As a key member of the Research team, you will play a role in establishing lab-based scientific approaches to support programs from early to late-stage research leading up to nomination of development candidates.
- Lead the implementation of novel and existing assay formats, techniques, and technologies to support Glycomine liposome technology platform.
- Design, develop, and implement in vitro cellular disease models, multiplex plate-based assays, and other techniques for mechanistic proof of concept studies and identification of relevant biomarkers.
- Execute biochemical, mammalian cell based in vitro and ex-vivo assays to support current and new programs.
- Collaborate with internal research teams and external groups/CROs to drive research projects.
- Contribute to scientific ideas and evaluating key hypotheses that advance company technologies. Actively participate in scientific discussions and drive research efforts for new projects enabling Go/No Go decisions.
- Document, compile, and interpret experimental data, ensuring proper QC and validation. Present research outcomes to stakeholders throughout the company in internal project teams and companywide meetings.
- Expertise in molecular and cellular biology techniques, such as cell culture, DNA/RNA isolation, PCR, western blotting, and cell-based and bioanalytical assays such as cell proliferation, ELISA, MSD, flow cytometry, mass spec to characterize effects of drug treatment on cells lines in vitro and in blood or tissue samples.
- Innovative and creative individual with the ability to work independently and in a team environment, to prioritize and execute experimental design and data analysis, and to take ownership of multiple projects.
- Well organized and demonstrated ability to prepare technical reports, summaries, protocols, etc.
- Excellent verbal and written communication skills are essential.
- Highly motivated with strong interpersonal skills to work in a collaborative team environment.
Ph.D. in biochemistry, cell or molecular biology, pharmacology, medical science, or related fields with 2 – 5 years of post-doctoral training or experience in the biotech or pharmaceutical industry. Title will be commensurate with experience.
Glycomine is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(K), FSA, and much more.
To apply, please submit a cover letter and your resume to careers@glycomine.com or click the submit button below to send an email.
We are hiring across our organization. If you don’t see an open position that is a fit, and you think Glycomine may be the right place for you, please submit a cover letter and your resume to careers@glycomine.com.