CAREERS at Glycomine

We are developing new treatments for rare diseases

We are developing new treatments for rare diseases

Glycomine is driven to develop therapies that provide significant improvements to the quality of life for patients and families with serious rare diseases. Our team has a diverse background of drug development experience, scientific and medical expertise, and a spirit of collaboration and teamwork. We are always looking for passionate and talented individuals who share our mission.

Diversity and Equal Employment Opportunities

Diversity and Equal Employment Opportunities

Glycomine is an equal opportunity employer, and we are dedicated to creating an inclusive environment for all employees. We respect the diversity of our workforce and applicants and encourage the expression of different cultures, backgrounds, and viewpoints.

East and West Coast Offices

East and West Coast Offices

We are located in major life science industry hubs in San Francisco, Boston, and Research Triangle Park where our team can access resources and come together. We also support remote and at-home work.

WORKING AT GLYCOMINE

Passion

Collaboration

Patient-Centric

Flexibility

Science-Driven

BROWSE CAREER OPPORTUNITIES

Director/Sr. Director, Analytical Chemistry

Research Triangle Park, NC

About Glycomine

Glycomine is driven to develop therapies that provide significant improvements to the quality of life for patients and families with serious rare diseases. Our team has a diverse background of drug development experience, scientific and medical expertise, and a spirit of collaboration and teamwork. This is an exciting period of growth for the company, and we are seeking passionate and talented individuals who share our mission.

 

About the Role

Reporting to the Vice President of Pharmaceutical Development and CMC, the Director, Analytical Chemistry will lead analytical development activities for clinical and preclinical programs by overseeing the work of contract laboratories and contributing a combination of technical expertise and collaboration skills to the drug development process. This is a unique opportunity to build the Analytical Chemistry function from the ground up while being a hands-on contributor to the success of our growing pipeline.

 

Responsibilities:

- Oversee the analytical development activities at contract laboratories performing GMP and R&D activities on both drug substance and drug product

- Serve as Analytical Chemistry subject matter expert supporting clinical phase and pipeline projects

- Develop and validate effective and efficient analytical methods for raw materials, in-process control, finished drug product release, and stability testing for drug substance and drug product

- Interpret technical results and convey their implications to internal and external stakeholders

- Evaluate stability studies to determine product shelf-life and set specifications

- Manage analytical data and generate relevant technical reports to support future regulatory submissions

- Key contributor to the writing and review of CMC sections in regulatory dossiers

- Represent the Analytical Chemistry function in regulatory inspections and responses

- Collaborate cross-functionally to ensure that analytical development activities are aligned with other aspects of project plans, timelines, and resources

- Manage the administrative aspects of analytical development outsourcing, including budgets, project timelines, forecasts, invoices, and contracts

- Direct or participate in compliance enhancement; required to advance company to support late-stage clinical trials and commercialization

- Direct chemical characterization studies to support the pharmaceutical development requirements

- Key stakeholder in technical transfer activities, process/product troubleshooting, and technical comparability studies

 

Candidate Profile:

- Prefer a Ph.D. with 10+ years of relevant industry experience, or a master’s degree with 15+ years of relevant industry experience

- Experience with selecting and managing contract laboratories

- Deep expertise in analytical method development and validation for small molecules; additional biologics/proteins expertise a plus

- Experience with liposomes or lipid nanoparticles; experience with injectables a plus

- Experience implementing drug development programs (i.e., shelf life setting, impurities, etc.)

- Extensive understanding of ICH guidelines and other regulatory requirements

- Experience contributing to regulatory filings and inspections

- Skilled interpersonal communicator; able to convey complex information clearly

- Team-player who thrives in a collaborative culture

- Willingness to be a hands-on contributor in a start-up environment

- Experience with DOE and using JMP® Software for data tracking and analysis is a plus

- Experience using Microsoft Project for project management is a plus

- Previous experience with HPLC, UPLC, GC, CAD, Dynamic Light Scattering, IR, and other standards pharmaceutically relevant analytical techniques for drug product and drug substance characterization

- Position is remote with a strong preference for candidates located in Research Triangle Park, NC

- Up to 10% travel expected for vendor management

 

Glycomine is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(K), FSA, and much more.

 

To apply, please submit a cover letter and your resume to careers@glycomine.com or click the submit button below to send an email.

SUBMIT APPLICATION

Scientist/Senior Scientist – Molecular and Cellular Biology Research

San Carlos, California

About Glycomine

Glycomine is driven to develop therapies that provide significant improvements to the quality of life for patients and families with serious rare diseases. Our team has a diverse background of drug development experience, scientific and medical expertise, and a spirit of collaboration and teamwork. This is an exciting period of growth for the company, and we are seeking passionate and talented individuals who share our mission.

 

About the Role

Reporting to the Head-Translational Sciences, the successful candidate will play an important role in the advancement of new therapeutic indications as well as supporting current pipeline programs. In this role, you will lead and direct efforts to support Glycomine’s pipeline project expansion by developing and implementing novel biochemical and cell-based assays as well as contributing to translatable pharmacodynamic biomarker discovery. As a key member of the Research team, you will play a role in establishing lab-based scientific approaches to support programs from early to late-stage research leading up to nomination of development candidates.

 

Responsibilities:

- Lead the implementation of novel and existing assay formats, techniques, and technologies to support Glycomine liposome technology platform.

- Design, develop, and implement in vitro cellular disease models, multiplex plate-based assays, and other techniques for mechanistic proof of concept studies and identification of relevant biomarkers.

- Execute biochemical, mammalian cell based in vitro and ex-vivo assays to support current and new programs.

- Collaborate with internal research teams and external groups/CROs to drive research projects.

- Contribute to scientific ideas and evaluating key hypotheses that advance company technologies. Actively participate in scientific discussions and drive research efforts for new projects enabling Go/No Go decisions.

- Document, compile, and interpret experimental data, ensuring proper QC and validation. Present research outcomes to stakeholders throughout the company in internal project teams and companywide meetings.

 

Candidate Profile:

- Expertise in molecular and cellular biology techniques, such as cell culture, DNA/RNA isolation, PCR, western blotting, and cell-based and bioanalytical assays such as cell proliferation, ELISA, MSD, flow cytometry, mass spec to characterize effects of drug treatment on cells lines in vitro and in blood or tissue samples.

- Innovative and creative individual with the ability to work independently and in a team environment, to prioritize and execute experimental design and data analysis, and to take ownership of multiple projects.

- Well organized and demonstrated ability to prepare technical reports, summaries, protocols, etc.

- Excellent verbal and written communication skills are essential.

- Highly motivated with strong interpersonal skills to work in a collaborative team environment.

 

Education

Ph.D. in biochemistry, cell or molecular biology, pharmacology, medical science, or related fields with 2 – 5 years of post-doctoral training or experience in the biotech or pharmaceutical industry. Title will be commensurate with experience.

 

Glycomine is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(K), FSA, and much more.

 

To apply, please submit a cover letter and your resume to careers@glycomine.com or click the submit button below to send an email.

SUBMIT APPLICATION

We are hiring across our organization. If you don’t see an open position that is a fit, and you think Glycomine may be the right place for you, please submit a cover letter and your resume to careers@glycomine.com.